[4] He played wide receiver, defensive back and returned kicks for the McQueen high school football team and was named first-team All-Northern Nevada and honorable mention All-State as a senior.

[12] He was named the Pac-12 Offensive Player of the Week after catching seven passes for 196 yards and three touchdowns in a 38–34 win over Washington State on October 12, 2019.

[18] On August 23, 2020, Aiyuk sustained a hamstring injury in training camp, resulting in him being inactive in Week 1.

[19] He made his NFL debut in Week 2 against the New York Jets and recorded two receptions for 21 yards in the 31–13 victory.

[20] In Week 3 against the New York Giants, Aiyuk recorded 101 yards from scrimmage and his first career rushing touchdown during the 36–9 win.

[22] In Week 4, against the Philadelphia Eagles on NBC Sunday Night Football, he had a 38-yard rushing touchdown in the 25–20 loss.

[23] He became the first wide receiver since the NFL-AFL merger to record two rushing touchdowns in his first three professional games.

[24] He recorded his first professional 100-yard game with six receptions for 115 yards in a 33–6 victory over the New England Patriots in Week 7.

[35] On Week 2, against the Los Angeles Rams, Brandon Aiyuk injured his shoulder on his first catch of the game.

[40] In the third quarter of the game, Aiyuk recorded a 51-yard reception off a pass that was deflected off of Kindle Vildor's helmet that helped get the 49ers into scoring position.

[41] In Super Bowl LVIII, Aiyuk had three receptions for 49 yards in the 25–22 overtime loss to the Kansas City Chiefs.