[9] The San Francisco 49ers selected McGlinchey in the first round (ninth overall) of the 2018 NFL draft.

[14] McGlinchey entered training camp slated as the starting right tackle, replacing Trent Brown who departed via trade.

He helped the 49ers beat the Minnesota Vikings and Green Bay Packers to reach Super Bowl LIV.

[20] He suffered a torn quadriceps in Week 9 and was placed on injured reserve on November 10, 2021, ending his season.

[22] On September 18, 2024, McGlinchey was placed on injured reserve after suffering an MCL sprain during the Broncos' Week 2 matchup against the Pittsburgh Steelers.

[26] McGlinchey's first cousin, Matt Ryan (their mothers are sisters), is a retired NFL quarterback who played for the Atlanta Falcons and the Indianapolis Colts.

[29][30][31] They have a son, born August 2024, named Michael Sean McGlinchey III, whom they call "Tripp".