[3] Two days before the first game of his freshman year, Lowe tore the anterior cruciate ligament in his left knee, which caused him to be redshirted and miss the entire season.

[6] Two days before the 2015 Major League Baseball draft, Lowe suffered a broken fibula as the Terrapins lost to the Virginia Cavaliers in the NCAA super regional.

With Charlotte he hit .311/.403/.524 with nine home runs and 46 RBIs in 90 games and was named the MVP of the Florida State League.

[11] Lowe began the 2018 season with the Biscuits and also played for the Durham Bulls of the Class AAA International League.

Lowe was named to the 2018 MLB Pipeline second team of the year after hitting .297/.391/.558 with 22 home runs in 380 at bats.

On March 20, 2019, Lowe signed a six-year contract extension, with two options, with the Rays for a reported $24 million guaranteed.

[19] On August 21, Lowe suffered a left quad strain while rehabbing with Durham, but he returned to the majors on September 22.

Lowe was named team MVP by the Tampa Bay members of the Baseball Writers' Association of America.

In-game 2 of the World Series against the Los Angeles Dodgers, Lowe broke out of his slump, hitting two home runs.

[24] He finished the season hitting .247/.340/.523 with 39 home runs and 99 RBIs in 149 games, while coming in 10th in American League MVP voting.

Lowe began the 2022 season starting off slow, ending the month of April batting .177 with 3 Home Runs and 8 RBI.

On April 21, Lowe hit a two-run walk-off home run against Reynaldo Lopez of the Chicago White Sox.

[28] On August 23, Lowe hit a walk-off single in the 10th inning against Brent Suter of the Colorado Rockies.

[29] On September 5, he hit a three-run walk-off home run in the 11th inning against Kenley Jansen of the Boston Red Sox.