After spending the following season with the Omaha Ak-Sar-Ben Knights of the American Hockey League (AHL),[3] Prust made his NHL debut on November 1, 2006, against the Detroit Red Wings.

[4] Midway through the 2008–09 season, Prust would be sidelined with injury after suffering a broken jaw due to being elbowed by Cam Janssen of the St. Louis Blues.

[25] Prust's main reason for signing the tryout was to fulfill his childhood dream of playing for the Maple Leafs, the team he grew up cheering for.

[24] After an unremarkable training camp, along with stiff competition for role players on the Leafs roster, he was released by the team on October 11, 2016,[26] He then embarked on his first overseas stint in late November 2016 after signing with the Thomas Sabo Ice Tigers of the German top-flight Deutsche Eishockey Liga (DEL).

[28] Vying for another attempt at an NHL comeback, Prust signed a PTO contract to attend the Los Angeles Kings' training camp prior to the 2017–18 season.

[30] Although he did not formally announce his retirement from professional hockey, Prust signalled the conclusion of his 12-year playing career in joining his former major junior club, the London Knights, as a coach on November 29, 2017.

[41] Morin had been a cast member on three seasons of the Canadian reality series Hockey Wives and is a popular host of her own talk show in Quebec, as well as starring in her first feature-length film.

[43] In 2020 Prust's charitable foundation launched a campaign to raise money for families of sick children to find accommodations in London during the COVID-19 pandemic in Ontario.

Prust was criticized after, in an August 2021 Twitter exchange related to vaccines, he replied to a woman with a post declaring that he hoped she would be subjected to forced prostitution.

[46] Prust had, for a time leading up to this, generated controversy for polarizing and combative Twitter exchanges on subjects such as racial relations and the 2020 United States presidential election (in which he was opposed to the candidacy of Democrat Joe Biden).