Scherff was also on the school's track & field team, where he was a standout shot putter and discus thrower, earning All-State recognition.

[5] After redshirting his initial year at Iowa, Scherff saw action at left guard in eleven games on the season, starting three.

[14] Many scouts and analysts were conflicted over his future position in the NFL, split on whether he was better suited to play offensive tackle or guard.

[19][20][21] He entered training camp competing with Morgan Moses for the starting right tackle position but was moved to right guard prior to the beginning of the regular season.

Since he was able to handle bull rushes well, he was thought to better suit the right guard position and be responsible for a smaller area where his power would be more useful.

[22] Offensive line coach Bill Callahan named him the Redskins’ starting right guard to begin the season after winning the job over Spencer Long in the preseason.

He started all 16 regular season games, played 752 snaps, and helped the Redskins finish first in the NFC East with a 9–7 record.

[31][32] An impending free agent in 2020, the team placed the non-exclusive franchise tag on Scherff prior to the start of the new league year, with him agreeing to it on April 8, 2020.

[33][34] He was placed on injured reserve on September 22 following a MCL sprain he suffered during a Week 2 game against the Arizona Cardinals before being reactivated on October 16, 2020.

[39] In March 2021, Washington placed another non-exclusive franchise tag on Scherff, worth $18 million, which he signed days later.

[44] He missed the Week 15 and 16 games against the Philadelphia Eagles and Dallas Cowboys after being placed on the COVID-19 reserve list for a second time on December 20, 2021.