[2] A pampered dog (Brandy) and an easily excited rabbit (Mr. Whiskers) face a new life of challenges together when they fall out of an airplane and become stranded in the Amazon rainforest.

In the meantime, both she and Mr. Whiskers work together and build an unlikely but genuine friendship despite having a lot of differences, adapt by exploring the environment, and making friends with the native animals.

Brandy makes attempts to get the jungle to become a civilized society by introducing elements such as fashion, hygiene, and shiny rocks, their type of currency.

They redecorate the treehouse by giving the interior a more "homey environment", which includes flowery wallpaper, tasteful decor and an indoor bathroom (this was after Mr. Whiskers' new "dream house" was destroyed).

They develop clothing, consumer products, restaurants, theme parks, TV commercials, a boy band called "Sugartoad" and a shopping mall.