He played college football for the Ohio State Buckeyes and was their starting quarterback from 2011 to 2013, before moving to the wide receiver position in 2015 after sustaining a shoulder injury.

[4] Miller committed to Ohio State on June 3, 2010, under then-head coach Jim Tressel.

Miller also had scholarship offers from Alabama, Cincinnati, Florida, Georgia, Illinois, Kentucky, Michigan, North Carolina, Notre Dame, Tennessee, Southern California, West Virginia, and Wisconsin.

[11] His second career start proved to not be so successful, as the Buckeyes lost 10–7 against Michigan State.

[13] In his third career start against Nebraska, Miller completed 5 of 9 passes for 95 yards and a touchdown,[14] before leaving the game with an ankle injury in the 3rd quarter.

[24] After the season, Miller became the seventh Ohio State player to take home the conference's Freshman of the Year accolade.

[38] He was named the Big Ten Conference Offensive Player of the Year in recognition of his successful season.

With just over 11 minutes left in the 4th quarter of the Orange Bowl, he injured his throwing shoulder completing a go-ahead touchdown pass to Carlos Hyde.

The injury eventually required surgery in the offseason and contributed to him switching from quarterback to wide receiver.

[49] He finished ninth in the 2013 Heisman Trophy voting and was once again named the Big Ten Offensive Player of the Year.

[52] His injury opened the door for J. T. Barrett and Cardale Jones to contribute at the quarterback position for the eventual National Champions.

This decision was a result of his shoulder injury a year before[55] Miller joined a receiving corps that included Michael Thomas, Jalin Marshall, and Curtis Samuel, as well as Ezekiel Elliot in the backfield.

[56] In the opening game of the 2015 season, he scored a rushing and receiving touchdown in Ohio State's 42–24 victory over Virginia Tech.

[64] He entered training camp competing with Jaelen Strong, Cecil Shorts, Keith Mumphery, Will Fuller, Wendall Williams, and Quenton Bundrage to be one of the Texans' starting star wide receivers.

[65] Miller was named the Texans's third wide receiver on their depth chart behind DeAndre Hopkins and fellow rookie Fuller.

[69] On November 21, 2016, Miller caught his first career touchdown on a 12-yard pass from Osweiler in a 20–27 loss to the Oakland Raiders.

[70] In Week 13, against the Green Bay Packers, he left midway through the game after he suffered a shoulder injury while attempting to catch a pass from Osweiler.

[72] He finished his rookie season with 15 receptions for 99 receiving yards and a touchdown in ten games and six starts.

His most productive game statistically came against the Tennessee Titans in Week 13, where he had four receptions for 71 receiving yards in the 24–13 loss.