He played college football for the Notre Dame Fighting Irish, earning second-team All-American honors in 2015.

[5] He originally committed to play college football for the Penn State Nittany Lions on June 3, 2012, after receiving a scholarship offer while on a visit at the school.

[7] Sources: Fuller played sparingly as a freshman at Notre Dame, catching only six passes for 160 yards and a touchdown.

Fuller's 15 touchdowns were tied for third in Football Bowl Subdivision, behind Colorado State's Rashard Higgins and Alabama's Amari Cooper.

[19] He caught six passes for 113 yards, including an 81-yard touchdown, in a losing effort against Ohio State in the Fiesta Bowl.

[27] He was the second wide receiver taken in the 2016 NFL Draft, only behind Baylor's Corey Coleman, who went to the Cleveland Browns with the 15th overall pick.

[28] In his first NFL game against the Chicago Bears on September 11, 2016, Fuller had five receptions (on 11 targets from quarterback Brock Osweiler) for 107 yards and a touchdown as the Texans won by a score of 23–14.

[33] On January 7, 2017, Fuller made his postseason debut against the Oakland Raiders in the Wild Card Round, recording four receptions for 37 yards during the 27–14 victory.

[34] During the Divisional Round against the eventual Super Bowl LI champion New England Patriots, Fuller had three receptions for 16 yards in the 34–16 road loss.

[37] Fuller made his season debut during a Week 4 57–14 victory over the Titans, catching four passes for 35 yards and two touchdowns to go along with a four-yard rush.

[47] During a Week 8 42–23 victory over the Miami Dolphins, Fuller had five receptions for 124 yards and a touchdown before leaving in the fourth quarter with a knee injury.

[51] Without Fuller, the Texans finished atop the AFC South with an 11–5 record and lost to the Colts in the Wild Card Round by a score of 21–7.

[54] Fuller returned from his injury in time for the season-opener against the New Orleans Saints, recording two receptions for 69 yards in the narrow 30–28 road loss.

[60] In the Divisional Round against the Chiefs, Fuller had five receptions for 89 yards during the 51–31 road loss despite a 24–0 lead in the second quarter.

[65] During a narrow Week 9 27–25 road victory over the Jacksonville Jaguars, Fuller recorded five receptions for 100 yards and a 77-yard touchdown.