[2] The opening two-chord piano riff and the lead falsetto singing voice of Larry Henley are notable features of the song.

The song features on the soundtrack to the 1998 comedy-drama film, Simon Birch, as well as in the 2004 Will Ferrell comedy, Anchorman: The Legend of Ron Burgundy.

"Bread and Butter" also was featured in The Brave Little Toaster Goes to Mars and in the Lizzie McGuire episode "She Said, He Said, She Said"; in the former, it featured in the opening scene after the opening credits (with Radio dedicating the song to Toaster, whom he called "a chrome-plated crony with a big heart full of crumbs"; Hearing Aid himself was introduced singing a variation of the Schmidt jingle version).

The song has also been used as a jingle for Savacentre, Spam, Doritos, Little Chef[4] and Quaker Rice Cakes; as well as in a 2018 television commercial for Walmart.

The song has been featured on numerous compilations, including Billboard Top Rock'n'Roll Hits: 1964 and Classic Rock (Time-Life Music).