The Romans maintained an auxiliary castle on Mons Brisiacus (which came from the Celtic word Brisger, which means waterbreak).

The Staufer dynasty founded Breisach as a city in the modern sense, but there had already been a settlement with a church at the time.

On December 7, 1638, Bernard of Saxe-Weimar, who was subsidized by France, conquered the city, which Ferdinand II and General Hans Heinrich IX.

From 1670, Breisach was integrated into the French state in the course of the "Politique des Réunions [fr]" followed by Louis XIV.

In the Treaty of Ryswick in 1697, Breisach was returned to the Holy Roman Empire, but then reconquered on September 7, 1703 by Marshal Tallard at the beginning of the War of the Spanish Succession.

In the French Revolutionary Wars in 1793, Breisach sustained heavy damage and then, in 1805, was annexed to the Grand Duchy of Baden.

One of Europe's largest wine cellars called Badischer Winzerkeller eG [de] is located in Breisach.

The Romanesque St. Stephansmünster [de], the cathedral in Breisach, has a late Gothic altar by an unknown craftsman (with the initials H.L.)

[7] A Jewish survivor who lived in town named Louis Dreyfuss, gave a report on his biography on some cases.