Ms Runyon resigned her position in 1926 due to failing health and was unable to secure a successor.
Both doctor and Ms Runyon were born in Trenton, Todd County, Kentucky.
Ms. Runyon was active in the civic affairs of Clarksville and was director of the Clarksville branch of the American Red Cross during World War I.
It was following the war that Ms Runyon organized the First Woman's Bank of Tennessee after being challenged to do so by a local business.
A fall in 1926 led to declining health and her resignation as bank director, eventually dying as a result on February 3, 1929.