Brenden Santi (born 5 August 1993) is an Italy international rugby league footballer who plays as a prop, second-row or loose forward for the York Knights in the RFL Championship.

He played his junior rugby league for the Chester Hill Hornets before being signed by the Canterbury-Bankstown Bulldogs.

In 2010, Santi was a part of the Canterbury-Bankstown Bulldogs' NYC squad but didn't play a game.

Coach Ricky Stuart said, "Brenden ticks a lot of boxes in regards to the type of player we want to build our club around - no nonsense and tough with a high work rate.

In 2018, Santi re-joined the Townsville Blackhawks, after spending the entire 2017 season playing for the Roosters' feeder club, the Wyong Roos, in the New South Wales Cup.

[13] In the 2019 season, Santi played for French side Toulouse Olympique making 19 appearances.