[5] He stated that working with then head coach Fernando Diniz "weighed heavily" on his choice to move to the club.

[7] Brenner credited Diniz for encouraging him to return to the club and believing in him despite not finding regular minutes for São Paulo or Fluminense up to that point.

Prior to that, Brenner continued to be used sparingly, unable to breakthrough for São Paulo against first choice forwards, Alexandre Pato and Pablo.

[19] On 11 November 2020, Brenner scored a brace against Flamengo, becoming São Paulo's top goalscorer in a season since 2015 with 17 goals in 26 matches at that point.

[20] On 3 December, after going four matches without a goal, Brenner scored the second in a 3–0 victory over Goiás, a key result in the Série A title race.

[27] On 5 February 2021, São Paulo agreed to transfer Brenner to Major League Soccer club FC Cincinnati (FCC).

[28] The move was officially announced by FCC on 9 February, with Brenner joining the club as a young designated player for an incoming transfer fee of $13 million, the fourth highest in MLS history.

[29][30] Brenner made his debut in FCC's opening match away at Nashville SC on 17 April 2021, scoring the team's second goal from the penalty spot in the 12th minute of a 2–2 draw.

[31] On 17 July, Brenner scored his first goals from open play, netting a brace in his side's 5–4 away defeat to CF Montréal.

His request was not met and he remained with FCC for the duration of the 2022 season, leading the team with 18 goals, including 3 hat-tricks, and helping them secure their first ever playoff berth.