He played in Major League Baseball (MLB) for the Philadelphia Phillies, Houston Astros, Chicago White Sox, and Cleveland Indians.

From there, he progressed to the professional ranks and made his MLB debut in 2002 for the Phillies, pitching for the team until 2009, mostly as a starter, but also closing for a time.

Myers was a high school baseball teammate of former Jacksonville Jaguars defensive back, Rashean Mathis.

[1] Myers made his major league debut in the summer of 2002, starting on July 24 against the Chicago Cubs at Wrigley Field.

[3] He pitched his second career shutout in May and recorded a five-game losing streak from June 22 to July 23, receiving minimal run support from the Phillies offense.

[5] 2004 was Myers' strongest year on offense, posting a .196 batting average and tying for the team lead in sacrifice hits with Randy Wolf.

Following Gordon's return from the disabled list, Myers remained in the closer role due to his effectiveness in the position.

As the Opening Day starter and then the closer, Myers threw the first and last pitches of the 2007 season, and was on the mound as the Phillies clinched their first playoff spot in 14 years.

"[11] During spring training 2008, Myers spearheaded an elaborate prank on Kyle Kendrick involving a fake trade to Japan.

On October 2, Myers won his first playoff start by pitching seven innings against the Milwaukee Brewers, giving up two earned runs.

His key contribution in that game, however, was when he drew a two-out walk against CC Sabathia in the second inning that set the stage for Shane Victorino's clutch grand slam.

However, the possibility was shot down by Phillies manager Charlie Manuel who said Myers "has soreness, which is kind of normal because he missed so much time.

[24] On July 21, 2012, Myers was traded to the Chicago White Sox for pitching prospects Matthew Heidenreich and Blair Walters, as well as a player to be named later, which eventually became Chris Devenski.

[25] On January 1, 2013, Myers agreed to a one-year contract, with an option for a second year, with the Cleveland Indians, pending a physical examination.

[28][29] On June 23, 2006 Myers was arrested and charged with assault after witnesses saw him punching his wife Kim on a downtown Boston street after an argument.

[7] During a pre-trial hearing on October 5, 2006, Kim Myers indicated that she did not want her husband prosecuted, and despite the prosecutor's insistence of filing charges, the case was dismissed.