His research focuses on psychoacoustics, audiology, and the development and assessment of hearing aids (signal processing and fitting methods).

In his early career in the 1970s, Moore was mainly interested in fundamental research on loudness and pitch perception, masking effects, and speech recognition.

His text book An Introduction to the Psychology of Hearing[6] has been cited over 5600 times and has been translated into Japanese, Polish, Korean, and Chinese.

[8] Moore was one of the first researchers to present convincing evidence for the role of phase locking (the synchronization of nerve spikes to individual cycles of the filtered stimulus in the cochlea) in the perception of pitch.

[18] Moore collaborated in the development and evaluation of multi-channel compression hearing aids intended to compensate for the loudness recruitment experienced by most hearing-impaired people.

[19][20] He and his colleagues developed a dual-time-constant automatic gain control system that has been widely used in hearing aids and cochlear implants.

Brian Moore also contributed to the development of tests for assessing monaural and binaural sensitivity to the temporal fine structure of sounds.

They have shown that difficulties in speech perception are at least partly linked to reduced sensitivity to the temporal fine structure of sounds.