The Minnesota Twins selected Dozier in the eighth round of the 2009 Major League Baseball Draft.

Dozier played baseball for Itawamba Agricultural High School located in Fulton, Mississippi, becoming a local star in the town of 4,000.

[3] Dozier played for the Bethesda Big Train of the Cal Ripken Collegiate Baseball League in 2006.

[4] The Minnesota Twins selected Dozier in the eighth round of the 2009 Major League Baseball Draft.

[3] On May 13, Dozier hit his first career Major League home run, off Ricky Romero of the Toronto Blue Jays.

He finished the season batting .236/.307/.444 with 28 home runs and a career-high 148 strikeouts (ninth in the American League), and leading the majors in pull percentage (60.2%).

[6][12] Dozier was named a finalist for the 2015 American League Second Baseman (2B) Rawlings Gold Glove Award, alongside fellow second basemen Astros Jose Altuve and Tigers Ian Kinsler.

[13] On September 12, 2016, Dozier became the first American League second baseman to hit 40 home runs in a season, with a third inning shot against Daniel Norris of the Detroit Tigers.

In the 10th inning of the July 15 game against the Tampa Bay Rays, Dozier hit the first walk-off grand slam in the history of Target Field.

[6] On July 31, 2018, Dozier was traded to the Los Angeles Dodgers in exchange for Logan Forsythe and minor leaguers Devin Smeltzer and Luke Raley.

[20] In 47 games with the Dodgers he hit only .182/.300/.350 with 5 homers and 20 RBIs in 143 at bats, and was relegated to pinch-hitting duties in the playoffs.

[25] On February 23, 2020, Dozier signed a minor league contract with the San Diego Padres, with an invitation to spring training.