He previously played in MLB for the Chicago White Sox, Oakland Athletics and Toronto Blue Jays.

Semien signed a seven-year, $175 million contract with the Rangers following the 2021 season and won the World Series with the team in 2023.

He grew up pitching and playing infield in El Cerrito Youth Baseball, across the bay from San Francisco, and was a member of the area's All-Star teams.

[3] On September 3, 2013, the White Sox selected Semien's contract from the Triple-A Charlotte Knights and promoted him to the major leagues for the first time.

[5] On December 9, 2014, the White Sox traded Semien, Chris Bassitt, Rangel Ravelo, and Josh Phegley to the Oakland Athletics in exchange for Jeff Samardzija and Michael Ynoa.

[8] He showed power at the plate, finishing second on the team in home runs with 27, as he batted .238 with ten stolen bases.

[11] He was one of three finalists for a Gold Glove at shortstop in the American League, marking drastic defensive improvement from his previous seasons.

He finished third in American League MVP voting, behind only Shohei Ohtani and teammate Vladimir Guerrero Jr.[21] On December 1, 2021, Semien agreed to a seven-year, $175 million contract with the Texas Rangers.

[22] In 2022, Semien led the major leagues in plate appearances (724) for the second straight year and at-bats (657) and sacrifice flies (10; tied with Alex Bregman and Alec Bohm), and hit .248/.304/.429 with 26 home runs and 83 RBIs.

Semien became the fifth player in MLB history with at least 100 RBI in the leadoff spot, and won a Silver Slugger award.

[28] With the Rangers, Semien won the 2023 World Series as the team defeated the Arizona Diamondbacks in five games.