He made a guest appearance in the first season of Gene Roddenberry's Andromeda as Wayist religious leader Vikram Singh Khalsa.

George has done voiceover work in animated shows such as Batman: The Animated Series (as musician turned gangster Jimmy "The Jazzman" Peake); Handy Manny; Kim Possible as antagonist Duff Killigan, a Scotsman who uses exploding golf balls when attacking Kim and Ron Stoppable, Kim's sidekick; Avatar: The Last Airbender as Guru Pathik; Batman Beyond; Justice League (voicing Parasite, in a style similar to the first voice actor of Parasite, Brion James), Morgan Edge and President George W. Bush), MASK, Invader Zim, and Jedi Master Ki-Adi Mundi in Season 2 of Star Wars: The Clone Wars.

He has also appeared in video games like Star Wars: Knights of the Old Republic, Baldur's Gate, Ultimate Spider-Man, Mass Effect 3, EverQuest II and Final Fantasy XIV.

Early in his acting career, he was among the cast of 1985's The Care Bears Movie, and made guest appearances in the Canadian television series The Edison Twins, The Littlest Hobo, Comedy Factory and King of Kensington.

His other appearances include the role of Mr. Pashmutt on Desperate Housewives (in the 2005 episode "You Could Drive a Person Crazy") and Ali on American Dad!

He also voiced Sahin the Falcon, Stuart Black snd colonel edwardson in the Age of Empires III series.

He also voiced Captain Barbossa in the video game Kingdom Hearts II, a role he would reprise in Pirates of the Caribbean: The Legend of Jack Sparrow, Pirates of the Caribbean: At World's End, Disney Infinity, and Kingdom Hearts III.

In the 2008 indie romantic comedy Shades of Ray, he played the overbearing Pakistani father to a half-Pakistani, half-Caucasian (Zachary Levi) in the midst of questioning his prior policy of only dating white women.

George regularly voiced several characters on DC Nation's Green Lantern: The Animated Series, including Appa Ali Apsa, LANOS, and Brother Warth.

In 2013, George took up a recurring role in Once Upon a Time in Wonderland as an unnamed prisoner who is later revealed to be the Sultan of Agrabah and father of the show's principal antagonist: Jafar.