During his career, he played with the Sacramento Kings (where he made First Team All-Rookie in the 1994–95 season), Portland Trail Blazers, Miami Heat, Los Angeles Lakers and Phoenix Suns.

During summers, he spent most of his time working at area farms, cutting, housing, and stripping tobacco, digging potatoes and baling hay.

He was named to the Associated Press honorable mention All-American team in his junior year, after ranking second in the nation in field goal percentage with 65.4 percent.

Portland opened the playoffs with a 3–1 first-round win over the Minnesota Timberwolves, with Grant and Wallace both being used as defensive options against Kevin Garnett.

In the Western Conference Finals, the Trail Blazers faced the Los Angeles Lakers led by Pippen's former Chicago Bulls coach Phil Jackson and the duo of Shaquille O'Neal and Kobe Bryant.

Grant made an appearance (albeit as an in game model) in a memorable Sega Dreamcast commercial in 1999 where he was seen talking to Sonic the Hedgehog character Tails.

Miami won 50 games, and Mourning returned to the team in late March, but were swept in the first round by the younger Charlotte Hornets.

The Heat once again found themselves in the lottery, and would select Dwyane Wade in the draft to join sophomore Caron Butler before acquiring free agent Lamar Odom in the offseason.

The 2003–2004 season proved to be a major success for the rebuilding franchise, as the Heat overcame an 0–7 start to eventually make the playoffs as the 4th seed in the East led by the play of Odom, Jones and Wade.

During the summer of 2004, the Heat traded Grant (along with Caron Butler, Lamar Odom, and a future first-round draft pick) to the Los Angeles Lakers in exchange for superstar Shaquille O'Neal.

After being waived by the Celtics on October 27, 2006, Grant formally announced his retirement after lingering injuries had reduced his level of play for several seasons.

Brian worked with Greg Oden in the 2009 off-season in Columbus, Ohio, for the purposes of adding more toughness, basketball smarts, and miscellaneous advice.

[5] Grant's memoir 'Rebound: Soaring in the NBA, Battling Parkinson's, and Finding What Really Matters' was released in April 2021, co-authored by Ric Bucher.