A member of the Republican Party, he was elected to the Iowa House of Representatives in 2018, succeeding Zach Nunn in District 45.

Prior to his state legislative service, Lohse sat on the city council of Bondurant, Iowa, for eight years.

[9][10] With the winnings, the couple established the Lohse Family Foundation, funded the construction of a high school football stadium, and opened a grocery store in their hometown of Bondurant, Iowa.

[7] In August 2022, Fareway announced that it would acquire the Brick Street Market and Café from the Lohse family.

[13] Brian Lohse served on the Bondurant City Council for eight years before contesting Zach Nunn's open Iowa House of Representatives seat in District 30 as a Republican Party candidate.