Brian Plotkin played college soccer for Indiana University from 2002 to 2005, featuring in 90 games and accumulating 24 goals and 36 assists.

He was the runner-up for the 2005 Hermann Trophy Award and was also named NSCAA First Team All-American and Big 10 Player of the Year.

Plotkin played club soccer for the Chicago Sockers from the U12 to U19 levels and was a member of their U16 National Championship team in 2001.

In 2017, Dartmouth won its 4th consecutive Ivy League Title and was awarded the #15 seed in the NCAA Tournament.

In January 2018 Plotkin was hired as an assistant coach alongside Chad Riley at Notre Dame.