[7] In September 2007, Runge was part of an incident involving then Padres outfielder Milton Bradley and first base umpire Mike Winters.

After Carlos Beltrán of the Mets questioned a called strike, Runge walked in front of the plate to dust it off, saying some words to Beltran in the process.

[12] On June 28, 2007, Runge was at third base when Toronto Blue Jay Frank Thomas hit his 500th career home run off Minnesota Twins pitcher Carlos Silva.

Later in the game, Thomas was ejected by plate umpire Mark Wegner for arguing balls and strikes, with Toronto manager John Gibbons also getting thrown out.

The opposing manager objected the ball was foul, and for the first time in MLB history, instant replay (a process officially introduced a few days earlier) was used to review the play and uphold the umpires' ruling.

Runge served as home plate umpire for White Sox pitcher, Philip Humber's perfect game on April 21, 2012, at Safeco Field,[16] and the combined no-hitter of Seattle Mariners pitcher Kevin Millwood and five relievers on June 8, 2012, also at Safeco Field,[17] becoming the 10th Major League umpire to call balls and strikes for multiple no-hitters in the same season.

[18] He was the third-base umpire for the perfect game thrown by San Francisco Giants pitcher, Matt Cain, on June 13, 2012, at AT&T Park.

[21] Less than one week later, Runge was released from Major League Baseball, reportedly due to undisclosed violations of the MLB Drug Policy.