Brian Lee Sanches (born August 8, 1978) is an American former professional baseball pitcher.

In 1996, Sanches graduated Nederland High School in Texas where he played baseball, basketball, football, and ran track.

Later that year, Brian (along with Chris Tierney) was traded to the San Diego Padres for Rondell White.

He began the season with Scranton, but finally made his major league debut on June 1, 2006, pitching 2.0 innings and giving up one walk and three strike-outs.

After opening the 2012 season with the AAA Lehigh Valley IronPigs, he was placed on the Phillies' active roster on May 1 following the injury of reliever David Herndon.

On June 28, Sanches was called back up by the Phillies along with Jeremy Horst, to replace Chad Qualls, who was designated for assignment.

On August 2, 2012, Sanches made an agreement to join the Houston Astros organization with Triple-A Oklahoma City.

Against right-handed hitters, Sanches uses a slider as his main off-speed pitch, and he also throws the forkball to righties.