Brian Wallach (born October 9, 1980) is an American businessman, lawyer, and amyotrophic lateral sclerosis (ALS) research and patient advocate.

[3] After law school, Wallach worked on the first presidential campaign for Barack Obama, where he met his wife, Sandra Abrevaya.

[3] Originally visiting the doctor for a persistent cough, Wallach had also mentioned experiencing muscle tremors and weakness in his left hand and was told he probably had a progressive neurodegenerative disease.

[7] In April of the same year, Wallach testified before Congress, advocating for ALS patients and research funding while sharing "what it's like to live with a fatal diagnosis.

"[3] Wallach's testimony spurred a legislative process that eventually led to President Joe Biden's December 2021 signing into law of the Accelerating Access to Critical Therapies for ALS Act, while acknowledging the contribution, and detailing the story, of Wallach and Abrevaya.

[9] This bill, which Wallach co-authored with others, provides expanded access to medications being studied in clinical trials to those who have been previously unable to participate.

[11] A network of non-profits, including I AM ALS, advocated to move the bill forward, which the United States Senate passed in December 2020.

[12] In June 2022, Wallach threw out the first pitch before a Chicago Cubs game at Wrigley Field as part of Lou Gehrig Day to raise awareness for ALS.