An episode would begin with host John Nelson interviewing the couple, with questions about how the two met and their courtship.

[2] Announcer Jack McElroy would sing a song for the couple, who would then exit to an adjacent chapel to be married by one of around 30 clergymen retained by the show.

[3] After the ceremony, the newlyweds returned to the studio where they received wedding gifts provided by sponsors, such as refrigerators, stoves, silverware and jewelry, as a reward for participating in the program.

[5] Radio historian John Dunning wrote, "During its five-year run, Bride and Groom told the stories of almost 1,000 new couples.

On occasion, the show featured celebrity couples, such as radio personality Bud Collyer and actress Marian Shockley in 1948.