Brother and Sister (French: Frère et Sœur) is a 2022 French drama film directed by Arnaud Desplechin, starring Marion Cotillard and Melvil Poupaud as estranged siblings who are forced to reunite after two decades following the death of their parents.

[7][2] André Borkman attends a memorial service which is being held for Jacob, his brother-in-law Louis' son.

Five years later, Abel and his wife Marie-Louise are driving to their daughter Alice's opening night of a play[a] when they stumble upon an ice road.

It is the second time this happened; on the first, she tried to stop the novel's publication, which aggravated her delicate relationship with Louis and led them to become estranged.

After the play, Alice learns of the accident, goes to the hospital and meets her kid brother Fidèle.

After learning his parents will die soon, Louis decides to come back to Lille — despite not seeing any of his relatives for the past five years.

Alice reveals why she hates Louis: years before, she was an established actor, and he was a struggling writer who often asked her for money.

When the novel received an important prize, she started to realize she hated her now financially independent and famous brother.

A distraught Fidèle cannot make it to the morgue where he is expected to bring Marie-Louise's burial clothes, so Louis goes in his place.

Alice meets Lucia to inform her this is their goodbye, she plans to bury Marie-Louise and stop acting in the play.

Louis asks for Fidèle and his boyfriend Simon to leave and reveals to Alice he regrets all the years he loved her, not knowing she had always hated him.

On 12 April 2021, Arte France Cinéma announced they were backing Arnaud Desplechin's next film, Brother and Sister.

[6] Distributor Le Pacte released the film theatrically in France at the same time of its Cannes premiere.

[27] Eric Neuhoff of Le Figaro gave the film five stars, stating, "It's called grace.

"[26] Cahiers du Cinéma gave the film four stars, stating, "The beauty of Brother and Sister made our desire to meet Arnaud Desplechin urgent.

"[26] The Film Stage included Brother and Sister on its list of "The Best Undistributed Films of 2022", stating, Brother and Sister, Arnaud Desplechin's tale of feuding siblings who re-enter each other's orbits after their parents get in a car accident, is the sort of heightened melodrama that will have some viewers laughing or sneering (or some combination of both).

But if you're open to Desplechin's directorial whims or have an interest in fraught familial relationships, Brother and Sister is a compelling effort—defiant in its handling of conventional drama and unafraid to be as flawed as its characters.

"[28] In France, Brother and Sister was released to 296 screens, where it debuted at number four at the box office, selling 73,784 tickets.