In the late 1870s, the institute became a target of the anti-vivisection movement in England[1] and the building on Wandsworth road was destroyed by German bombs in 1944.
Brown's Will stated the purpose of his bequest for "founding, establishing and upholding an Institution for investigating, studying and, without charge beyond immediate expenses, endeavouring to cure maladies, distempers and injuries any quadrupeds or birds useful to man may be subject to, for and towards which purpose of founding, establishing and upholding such animal sanatory institution within a mile of either Westminster, Southwark or Dublin.” The funds were transferred to the University of London in 1858 and accumulated interest till 1871 to a value of £33,781.
149) a small archway on which is graven the legend “The Brown Sanatory Institution founded 1871.” On entering, one comes to a stable yard and, behind, a low building of one storey.
"The institute was supported by John Simon (1816-1904) pathologist and medical officer in the board of health for London.
Among the researchers who worked at the institute was a Viennese scientist, Emanuel Edward Klein, sometimes considered the father of British bacteriology.
The research he and his colleagues conducted at the Institution were published as in 1873 as the Handbook for the Physiological Laboratory along with John Burdon-Sanderson, Michael Foster, and Thomas Lauder Brunton.