[8] In 1935, as a celebration of the Repeal of Prohibition in the United States, Denver architect Alan Fisher designed "Ship Tavern"; one of four restaurants inside The Brown Palace.

[11] The lower levels of the tower are shared with the Brown Palace, including the Grand Ballroom and executive offices.

Past guests include the "Unsinkable" Molly Brown (she stayed at the hotel only a week after the Titanic disaster), infamous Denver crime boss Jefferson "Soapy" Smith, Dr. Sun Yat Sen (just before becoming the president of the new Republic of China), Denver Socialite Louise Sneed Hill, Queen Marie of Romania, John Wayne, and The Beatles.

Presidential guests include William Taft, Warren Harding, Harry S. Truman, Dwight D. Eisenhower, Ronald Reagan, and Bill Clinton.

[12][13][14] In Joan Didion's 1977 novel A Book of Common Prayer, the narrator, Grace Strasser-Mendana, lives at the Brown Palace after her parents' deaths.