[3][4] He also played the lead role in Werner Herzog's Where the Green Ants Dream (1984)[3] and portrayed Jedediah the pilot in Mad Max Beyond Thunderdome (1985).

[4] In the 21st century, Spence played the Mouth of Sauron in The Lord of the Rings: The Return of the King (2003),[5] the Trainman in The Matrix Revolutions (2003),[6] and Baxter in Disney's Inspector Gadget 2 (2003),[7] and voiced the character Chum in Finding Nemo (2003).

[8] He also portrayed Tion Medon in Star Wars: Episode III – Revenge of the Sith (2005)[9] and played Lord Rhoop in The Chronicles of Narnia: The Voyage of the Dawn Treader (2010).

[9] Spence portrayed the palaeontologist (Huxley) in the Australian performance of BBC's Walking with Dinosaurs: The Live Experience.

In his role, Spence narrated the activities of life-sized mechanical dinosaurs operated by teams of puppeteers and drivers.