Brule is a town in Douglas County, Wisconsin, United States.

The town takes its name from the nearby Bois Brule River, which flows north into Lake Superior.

Located near the primary trout spawning bed for western Lake Superior, Brule is a destination for serious fly fishermen from the around the world.

Four United States presidents, Calvin Coolidge, Herbert Hoover, Harry Truman, and Dwight Eisenhower, have summered near Brule in some of the many Adirondack-style lodges erected by prominent families from Minneapolis and Milwaukee.

[5] In 1899, Professor Ulysses Sherman Grant, of Northwestern University, inspected the Brule, Wisconsin area for ancient copper deposits.

[6] CIA chief of counterintelligence James Jesus Angleton had a home on the river.