The comic is characterized by lengthy and sometimes angst-ridden dialogue between the characters, occasionally punctuated by a single panel with a contemplative scene without words.

The storylines follow the life of Bruno (somewhat autobiographically) as she quits college, visits friends in various American towns, travels to Europe, falls into and out of relationships, and publishes her novel.

As the timeline of the comic follows real time, we gradually see Bruno evolving from a free-spirited college student into a more contemplative woman.

Bruno's face is based roughly on a sketch of an angel's head by Leonardo da Vinci.

[4] The webcomic eventually concluded on 14 February 2007, coinciding with the announcement of the tenth and final Bruno book.