He held the title of professor of composition at that same institute and he trained many notable contemporary Italian musicians, including Claudio Abbado, Emiliano Bucci, Elisabetta Brusa, Gilberto Serembe, Danilo Lorenzini, Roberto Cacciapaglia, Bruno Canino, Aldo Ceccato, Riccardo Chailly, Azio Corghi, Armando Gentilucci, Riccardo Muti, Maurizio Pollini, Uto Ughi, Angelo Paccagnini, Bruno Zanolini, Silvia Bianchera, Umberto Benedetti Michelangeli, Francesco Degrada, Massimo Di Gesu, Carlo Alessandro Landini, Massimo Anfossi, Caterina Calderoni, Barbara Rettagliati, Massimo Berzolla and many others.
He received many international awards for composition, including a prize from Accademia Nazionale di Santa Cecilia in Rome in the 1940s.
As a memoriam to Bruno Bettinelli, Milan's Edizioni Musicali European (EME), in collaborations with the magazines "Cartellina" and "Chorus," established a national competition for choral composition in his name.
His younger works incorporated a contrapuntal neoclassicism, influenced by Igor Stravinsky, Paul Hindemith and Béla Bartók and by the Italian composers Alfredo Casella, Goffredo Petrassi and Gian Francesco Malipiero.
His music flows into a free and personal chromatic language, always full of refined timbres and effectively eloquent gestures, endowed with formal structures of remarkable expressive rigour.