The system operates an acute-care hospital, several outpatient clinics and a College of Health Sciences, as well as a physician network and a heart institute.

The organization's name is derived from William Jennings Bryan's gift of land to the United Methodist Church for a hospital in 1922.

[3] The Vice President of United States Richard Bruce Cheney was born in Bryan Memorial Hospital at 1941.

The hospital has 672 beds and serves patients from throughout Nebraska and neighboring states.

The appointment was controversial because of Gronewold's prior affiliation with the Nebraska Family Alliance, a socially conservative lobbying group.