In 1969 his first work appeared as illustrations in Mallorn, the British Tolkien Society magazine,[5] followed in 1972 by a weekly strip in his college newspaper.

[citation needed] In the early-to-mid 1980s Talbot provided art for some of 2000 AD's flagship serials, producing three series of Nemesis the Warlock, as well as occasional strips for Judge Dredd.

Talbot moved to the U.S. market in the 1990s and principally worked for DC Comics on titles such as Hellblazer,[7] Batman: Legends of the Dark Knight, and Dead Boy Detectives.

Talbot collaborated with Neil Gaiman on The Sandman and provided art for the "Fables & Reflections", "A Game of You", and "Worlds' End" story arcs.

In 2006, he announced the graphic novel Metronome, an existential, textless erotically charged visual poem,[11][12] written under the pseudonym Véronique Tanaka.