It is currently the most successful and prominent comics publisher in Canada, publishing well-known comic artists such as Lynda Barry, Kate Beaton, Marc Bell, Chester Brown, Daniel Clowes, Michael DeForge, Guy Delisle, Julie Doucet, Mary Fleener, Joe Matt, Shigeru Mizuki, Rutu Modan, Joe Sacco, Seth, Yoshihiro Tatsumi, Adrian Tomine and Chris Ware.

Drawn & Quarterly reduced the number of serialized titles it published, focusing on book-form comics such as collections and graphic novels.

It also began publishing the works of Shigeru Mizuki, Susumu Katsumata, Yoshihiro Tatsumi, Oji Suzuki, and Seiichi Hayashi for the first time in English.

In 2015, the publisher produced a collection titled Drawn & Quarterly: Twenty-Five Years of Contemporary Cartooning, Comics and Graphic Novels, featuring of out-of-print work, remembrances, and essays by well-known writers such as Margaret Atwood.

[9] In November 2023, employees of Drawn & Quarterly formed a union with the Fédération du Commerce under the Confédération des Syndicats Nationaux, with certification from the Administrative Labor Tribunal of Quebec.

[10] In 2007, Drawn & Quarterly opened an English-language bookshop on Bernard Street in Mile End, Montreal, selling graphic novels, prose literature, non-fiction, poetry and fine art book.

In 2017, the store expanded and opened La Petite Librairie Drawn & Quarterly, a children's bookshop during the day and event space at night.

The store has hosted events with their own cartoonists such as Lynda Barry, Adrian Tomine, Chris Ware, Leanne Shapton, Seth, Chester Brown as well as novelists including Margaret Atwood, Neil Gaiman, Junot Diaz, Paul Auster, Sheila Heti, Miranda July, David Byrne, Gloria Steinem, Roxane Gay, Carrie Brownstein, Alison Bechdel and many more.

[citation needed] In 2004, Drawn & Quarterly began an imprint for non-comics art books called Petit Livre.