While spending a night out, Linna Yamazaki, a new employee at the Hugh-Geit Corporation (a Genom subsidiary), observes a Boomer that has “gone rogue”, causing destruction and attacking people.

Over the course of the series, the Knight Sabers go after rogue boomers, which frustrates AD Police officers Leon McNichol and his partner Daley Wong.

Genom is also frustrated by their actions as their chairman, Quincy Rosenkreutz, and his advisor Brian J. Mason seek to unlock more boomer technology to defeat and capture the Knight Sabers.

Later on, Sylia's younger brother Mackie, who is part-boomer, joins the Knight Sabers as an assistant alongside their lead mechanic, Nigel Kirkland.

The Knight Sabers’ hardsuits break down as a result of Galatea’s reactivation, and Sylia is forced to get Nigel and Mackie to build new ones based on liquid metal.

Galatea's influence causes boomers across Tokyo to go rogue, trapping the Knight Sabers and the AD Police officers inside their own buildings.

The Japanese government then orders a complete evacuation of Tokyo, the AD Police are shut down, and the Knight Sabers are forced to use Nigel's workshop as their new base of operations.

After retreating, Sylia retires from being an active member and sends Priss, Linna, and Nene to a Genom space station orbiting Earth to stop Galatea using the Motoslave that Nigel developed.

As Galatea subsumes the space station, Linna and Nene are overwhelmed and are forced to retreat back to Earth, crash-landing on a deserted island.

Initially they are suits of armour that the four Knight Sabers step into while wearing body stockings as close contact with skin and "plumbing" connections are required.

Sylia states that the reason there are no male Knight Sabers is because it was easier to find women who shared a similar shape to her than to redesign hardsuits for a different anatomy.

As the newest suit of the group, it has some of the most advanced features, including a pair of long, ribbon-like cutters with nanometer-thick mono-molecular edges that can slice through almost anything.

Her weaponry includes a railgun that can shoot high sectional density armor-piercing metal spikes into her opponents, armored gauntlets, and an incredibly powerful computer system and scanner array that lets her handle almost any field intelligence operations required of her.

The twenty-six episode anime series is directed by Hiroki Hayashi and features character designs by Hidenori Matsubara and Masaki Yamada.

Jason Bustard of THEM Anime Reviews gave the series a rating of 4 out of 5 stars, calling it a fitting tribute to the original Bubblegum Crisis.