The series revolves around teenage moe anthropomorphic girls who use machines attached to their legs to do aerial combat.

The light novel series follows the Suomus Independent Volunteer Aerial Squadron, focusing on a dogfighter named Tomoko Anabuki.

The main anime franchise follows Yoshika Miyafuji, a girl from the Fuso Empire who joins the titular Strike Witches to investigate the death of her father and help fight off the Neuroi.

In a postscript column in Comp Ace, Fumikane Shimada had mentioned his desire to use his Mecha Musume concepts across a variety of media, leading to the production of the Strike Witches OVA by Gonzo.

[10] However, at about the same time Fumikane was also contracted to create the character designs for Sky Girls, which had its televised run in late 2007.

During this time there was no word on the further development of a Strike Witches animated series, although promotional items such as plastic figures of the OVA's characters were released.

Not until December 2007 was the anime officially announced, after which details were slowly released, such as the casting of the remaining main characters that had no lines in the OVA.

The first, Strike Witches: Suomus Misfits Squadron (ストライクウィッチーズ： スオムスいらん子中隊, Sutoraiku Wichīzu: Iranko Chūtai), was written by Noboru Yamaguchi and illustrated by Hashigo Ueda.

[13] The Suomus Misfits Squadron series is set in a different time period and location from the anime, and uses a different cast of characters.

[14] The second light novel series, titled Strike Witches: Maidens' Volume (ストライクウィッチーズ：　乙女ノ巻, Sutoraiku Wichīzu: Otome no Maki), was written by Hidehisa Nanbō and illustrated by Hashigo Ueda.

The third light novel series Noble Witches (ノーブルウィッチーズ, Nōburu Wichīzu) is the stories about the 506th Joint Fighter Wing.

[17] There are ten manga series of Strike Witches: An original video animation directed by Kunihisa Sugishima and produced by Gonzo was released on January 1, 2007.

The YouTube and Crunchyroll broadcasts operate under a streaming window, allowing users to freely watch each new episode of the series on the day of their release for a set amount of time.

[61] A three-part OVA series produced by Silver Link titled Strike Witches: Operation Victory Arrow, which features three short stories taking place between the second anime season and the film, was released between September 20, 2014, and May 2, 2015.

aired from January 13 to March 31, 2021, with the cast and staff from Strike Witches: 501st Joint Fighter Wing Take Off!

[7] Produced by AIC, the film was released in Japanese theaters on March 17, 2012, and on DVD and BD on October 26 of that same year.

"Strike Witches: To Do What I Can" (ストライクウィッチーズ ～わたしにできること～, Sutoraiku Witchīzu ~Watashi ni Dekiru Koto~), performed by Yoko Ishida is used as the opening.

"Lili Marleen" (リリーマルレーン, Ririi Marureen), translated by Takaaki Suzuki, and performed by Minna-Dietlinde Wilcke (Rie Tanaka), is used as an insert song in episode 8.

In Funimation's release, Lamp of a Wish (願いの灯火, Negai no Tomoshibi), a song also sung by Rie Tanaka from the CD album for the Strike Witches: What I Can Do Along With You game, was substituted for Lili Marleen.

The single for "Strike Witches: To Do What I Can" was released on August 20, 2008, by Columbia Music Entertainment and also a version of "Bookmark A Head" performed by Misato Fukuen.

Additionally, five albums of character image songs were released by Columbia Music Entertainment: There are five games based on the Strike Witches franchise.