Sired by Saint Liam, a Breeders' Cup Classic winner who also won the Eclipse Award as the 2005 Horse of the Year, he is out of the mare Tuzia by Blushing John.
In his first race, going 6+1⁄2 furlongs (4,300 ft; 1,300 m) at Belmont Park, Buddy's Saint was first to cross the wire, but was disqualified and placed second for bumping another horse in the stretch.
Buddy's Saint outdueled odds-on favorite Tobaggon Slide and ran away with a 12-length victory under a hand ride by Jose Lezcano.
Buddy's Saint passed pacesetters Homeboykris and Citrus Kid on the turn and coasted to an easy 4+3⁄4 lengths victory over 20-1 longshot Peppi Knows.
While training for his return to the races in November 2010, he fractured his shoulder in a morning workout at Belmont Park and was euthanized on the track.