[3] The Buffalo Bar opened in 2000 and hosted performances by a large number of notable alternative and indie rock artists.

[11] Notable artists that played the Buffalo bar include: The Libertines, Keane, Hot Chip, Bloc Party, The Kooks, Art Brut, the Pains of Being Pure at Heart, Friendly Fires, Two Door Cinema Club, Martha Wainwright, Stereolab, Futureheads, Bombay Bicycle Club, the Long Blondes, the Magic Numbers, Ed Harcourt, the Zutons, Oneida, Part Chimp, Electrelane, and the Joy Formidable,[12] as well as others including the Horrors, Foals, Fiery Furnaces, Maxïmo Park, the Brian Jonestown Massacre, the Duke Spirit, We Are The Physics, Hope of the States, Animal Collective, Emmy the Great, Bis, the Maccabees, Jack Rose, Josh T. Pearson, Larrikin Love, Desperate Journalist, High Llamas, the Organ, Sleaford Mods, Thee Faction, Male Bonding, Colour Me Wednesday, Chris T-T, T.V.

Smith, Spearmint, the Popguns, Shrag, Savages, the Tuts, Factory Floor, Fat White Family, These New Puritans, the Nightingales, the Wolfhounds, the Cravats, the Homosexuals, KaitO, Victorian English Gentlemens Club, Zombina and the Skeletones, Pink Grease, Tiny Masters of Today, Blood Arm, Frank Turner, Scout Niblett, Jon Langford, the Featherz, Poppy and the Jezebels, Yummy Fur, Country Teasers, the Lovely Eggs, Future of the Left, Blood Red Shoes, Joanne Joanne, the Art Goblins and Keith Top of the Pops & His Minor UK Indie Celebrity All-Star Backing Band.

[13] Promotional videos were also filmed at the venue including for Electric Eel Shock, Comet Gain and the Ethical Debating Society.

"[14] The Buffalo Bar was one of a number of grassroots London music venues subject to closure during the same period, including Madame Jojo's,[17] 12 Bar Club,[18] Power Lunches,[19] The Grosvenor,[20] Passing Clouds[21] and The Silver Bullet[22] – prompting questions over the future of venues faced with the threat of "soaring rents..noise pollution orders, and developers".