Madame Jojo's was a venue for cabaret, burlesque, drag shows, and live music located on Brewer Street in the Soho area of the City of Westminster in the West End of London.

[1][3][2] The building the nightclub is in was previously, from the late 1930s to the early 1970s, the basement bar Jack of Hearts, with restaurant Isow's upstairs.

[1] Indie club night and music promoters White Heat started at Jojo's on Tuesdays in 2005, they put on early concerts there for artists such as Lorde, Jamie T, The XX, and Adele.

[1][2][3] This was due to a bouncer having been accused of pulling out baseball bats to attack a group throwing glass bottles outside of the venue, although he was later cleared of assault.

[13] After a new license was granted in December 2019, and following a renovation of the whole building, it was reported in July 2022 that the club would reopen in "spring 2023", however this failed to happen and there has as yet been no further news.