Due to delays in construction of their new ballpark, the team did not play their first home game until a month after the Federal League season had started.
In the league's second and final season, the team, then known as the Buffalo Blues, ended in sixth place with a 74–78 mark (.487), 12 games behind the Chicago Whales.
An unusual player who played for the Blues in 1914 was Ed Porray; the only major leaguer whose birthplace is not a place, but rather noted as "on a ship somewhere in the Atlantic Ocean," on December 5, 1888.
Between the Buffalo players who had experience in the American and/or National leagues were Hugh Bedient, Walter Blair, Hal Chase, Tom Downey, Howard Ehmke, Ed Lafitte, Harry Lord and Russ Ford.
Due to border travel restrictions stemming from the COVID-19 pandemic, the Blue Jays played their home games at Buffalo's Sahlen Field (a facility designed to be easily upgraded to MLB standards) for the 2020 and part of the 2021 Major League Baseball season, marking the first major league games played in Buffalo in 104 years.