The interactive exhibit gives a hands-on approach to health, exploring topics such as healthy choices, body systems, the heart, medical technology, genetics, and related research done in Western New York.

Specimens include 50-million-year-old birds, feathers and flowers, the earliest known land plant, a trilobite trapped in a seashell nearly 400 million years ago, a cast of a Tyrannosaurus rex skull, a compression fossil replica of Archaeopteryx, Triceratops horridus, Deinonychus antirrhopus, and Allosaurus fragilis.

Hands-on exhibits present the basics of nanoscience and engineering, introduce some real world applications, and explore the societal and ethical implications of this new technology.

In 2010 the museum began an extensive renovation campaign, the goal of which was to convert the old diorama based exhibits into interactive Science Studios.

This campaign culminated with the renovation and reopening of the Kellogg Observatory in July 2018 Whem Ankh was an exhibit running from 1998 to 2013 displaying artifacts from the daily life as lived on the banks of the lower Nile River 2,200 years ago.