The Lucerne featured a row of "Ventiports," on the front fenders, corresponding to the number of cylinders in each bank of its V-engine — three on each side for the V6 or four for the V8.

GM also lead all other automakers in Strategic Vision's Total Quality Index (TQI) [2] The Super trim level was introduced at the 2007 New York Auto Show, featuring the 4.6 liter Northstar L37 V8; revised trim; an increase of 17 hp (13 kW) horsepower, and revised front styling and a rear spoiler.

All Lucernes received modest mid-cycle updates in 2008, adding optional blind spot monitoring and lane departure warning system and revised exterior colors.

[citation needed] The 2009 Lucerne received small upgades, including a new base engine, the 3.9 L GM High Value LZ9 V6, Bluetooth phone connectivity, and XM NavTraffic.

[9] The IIHS also found that 2006-08 model year Lucerne had the highest fatality rate in the large 4-door car class.