The old village center lies along the Buiksloterdijk (a dyke), more specifically at the Northern IJdijk, between Nieuwendam and Oostzaan.

Due to a dyke breach in 1514 south of the (not yet reclaimed) Buikslotermeer, a large amount of the original buildings were washed away and contact between the settlements of Buiksloot and Schellingwoude was broken off.

From the 17th century onwards, the population of Buiksloot exceeded that of the Schellingwoude settlement, of which it was part until the French era.

In 1659, five cities (Amsterdam, Hoorn, Edam, Monnickendam and Purmerend) agreed to build a network of tow-canals (Zesstedenweg) with a regular trekschuit service.

In Buiksloot there was a crossroad from the IJ to the tow-canal northwards, which uses the western ring canal from the reclaimed Buikslotermeer in 1627.

At the start of the Eighty Years' War/Dutch Revolt (1568-1648) hagepreken (sermons) were held in Buiksloot, among other places.

As early as 1572, Waterland assumed a pro-prince stance, while Amsterdam remained loyal to the Spanish king until 1578.

Old village buildings of Buiksloot on the dyke of the Buikslotermeer, alongside the ring canal, were demolished for this purpose.

Also in the western part of the village, between the Buiksloot church and the Buiksloterbreek, many old dyke structures disappeared.

Part of the Buiksloot dyke was also excavated for the construction of the Nieuwe Purmerweg (a road), which never saw the light of day.

Buiksloot, along with the garden villages dating from the 1920s, has been part of the Rijksbeschermd gezicht Amsterdam-Noord (state protected) since 2014.

Near Buiksloot, close to the Noordhollandsch Kanaal, lies the chalk mill D'Admiraal (The Admiral).