[1] Burbank Boulevard travels east–west across almost the entire San Fernando Valley.

The western section starts at the entrance to Hidden Hills and travels through most of Woodland Hills, while the eastern section travels from Tarzana, through Encino, Sherman Oaks, Valley Village, North Hollywood, and into Burbank.

Metro Local Line 237 runs along Burbank Boulevard between Sherman Oaks and North Hollywood.

[3][4] The G Line's Valley College station is located at Burbank Boulevard and Fulton Avenue in Sherman Oaks.

[5] Notable landmarks on Burbank Boulevard include (from west to east): Kaiser Permanente Woodland Hills Medical Center, Warner Center Corporate Park, Providence Tarzana Medical Center, Sepulveda Recreation Area, Balboa Golf Course, KSPN (AM) radio towers, and the North Hollywood Police Station.