The Bureau of South and Central Asian Affairs (SCA) is an agency within the United States Department of State that is responsible for the U.S. government's relations with countries in the South and Central Asian region.

After six years of trying, Congress allocated the funds to create an independent Bureau of South Asian Affairs in 1991.

[2] Pursuant to the Foreign Relations Authorization Act for Fiscal Years 1992 and 1993,[3] the Bureau of South Asian Affairs was established on August 24, 1992, after having been a part of the Bureau of Near Eastern and South Asian Affairs since 1958.

[4] In February 2006 the bureau absorbed the Office of Central Asian Affairs from the Bureau of European and Eurasian Affairs.

The offices of the Bureau of South and Central Asian Affairs direct, coordinate, and supervise U.S. government activities within the region, including political, economic, consular, public diplomacy, and administrative management issues.