Nine business routes of Interstate 44 (I-44) exist, all of them within the state of Missouri.

From the highway's western terminus to downtown Joplin it is concurrent with Route 43.

In downtown Joplin, the highway then turns east onto 7th Street and runs concurrent with Route 66 until I-44/I-49/US 71 near Scotland.

turns north at Glenstone Avenue, concurrent with U.S. Route 65 Business (US 65 Bus.).

Robert area begins on the westside of Waynesville at exit 156.

continues east, past the Pulaski County Courthouse in the old part of the city (where Route 17 turns off north).

The route then climbs a steep hill and rounds a curve underneath a rock overhang painted like a frog.

continues into St. Robert, and the lanes split with a Roadside Park between them.

Robert I-44 business loop with the main north gate of Fort Leonard Wood.

The highway is lined with businesses and is also called Missouri Avenue, whose name continues into Fort Leonard Wood.

This portion of road was designated a business loop of I-44 after the Interstate was built to bypass the town.

US 50 was then rerouted onto I-44, making this portion a business loop after US 66 was removed from the area in 1979.