Charles Edward "Buster" Brown (August 31, 1881 – February 9, 1914) was an American Major League Baseball pitcher from 1905 to 1913.

He played for the Philadelphia Phillies, St. Louis Cardinals, and Boston Braves.

He has the record for the lowest career winning percentage of any pitcher with a minimum of 150 decisions at .327 for a record of 51 wins and 105 losses.

Brown died of blood poisoning following an operation to remove a growth under his right arm.

This biographical article relating to an American baseball pitcher born in the 1880s is a stub.