[3] In his freshman year at Clemson, he posted 5–2 record with a 4.76 earned run average (ERA) and tallied 70 total strikeouts over 51 innings pitched.

[5][6] Strider missed the 2019 season after suffering a torn ulnar collateral ligament in his elbow, which required Tommy John surgery.

[22] On September 1, he broke the Braves' record for most strikeouts in a nine-inning game, fanning 16 Colorado Rockies batters in eight shutout innings.

[33] Strider recovered from his injury for the 2022 postseason and was placed on the National League Division Series roster,[34] being named the starter in Game 3 versus the Philadelphia Phillies.

At the end of the season, Strider finished second in the National League Rookie of the Year Award balloting to teammate Michael Harris II.

[35] This is the first time that two Braves players have finished first and second in Rookie of the Year voting since Craig Kimbrel and Freddie Freeman in 2011.

[38] On August 1, Strider broke his own previously set record for the fastest to attain 200 strikeouts in a season, doing so in 123.1 innings pitched.

[41] In 2024, Strider was named the Opening Day starting pitcher for the first time in his career,[42][43] supplanting Max Fried.

After recovering from Tommy John surgery, Strider began throwing a four-seam fastball, and became more willing to pitch in the upper region of the strike zone.

As the Braves had retired 29 for pitcher John Smoltz, and 28 was assigned to Matt Olson, Strider wore 65 during his rookie season, then subsequently chose 99 to commemorate Rick Vaughn, a character in the 1989 film Major League.

[62] Strider publicly supports left-wing politics and has praised former Democratic Party presidential candidate Bernie Sanders.