He was a five-time County Player of the Week and helped lead the Eagles to an 8-4 record and the second-round of the state playoffs, where Etowah won its first Region 5A title in school history.

He caught 17 balls for 363 yards and a score as a receiver, and also tallied 89 tackles from the secondary with 66 solo stops, had one interception and a fumble recovery.

For his senior season, he earned All-county, All-region and All-state honors, and was named as the Cherokee County Player of the Year.

[11] Throughout training camp, Skrine competed for a job as a backup cornerback against Ramzee Robinson, Coye Francies, and Dimitri Patterson.

[15] On December 18, 2011, Skrine recorded two solo tackles, a pass deflection, and made his first career interception during a 20–17 overtime loss at the Arizona Cardinals in Week 15.

He intercepted a pass attempt by quarterback John Skelton that was originally intended for Early Doucet and returned it for five-yards in the fourth quarter.

Head coach Pat Shurmur named Skrine the fourth cornerback on the depth chart to begin the season, behind Joe Haden, Sheldon Brown, and Dimitri Patterson.

[23][24] Head coach Rob Chudzinski named Skrine a starting cornerback to open the regular season, alongside Joe Haden.

[25] On September 15, 2013, Skrine made his first start of the season and collected a season-high nine combined tackles and broke up a pass in the Browns' 14–6 loss at the Baltimore Ravens in Week 2.

[30] Head coach Mike Pettine opted to instead name Skrine the starting cornerback to begin the regular season, along with Joe Haden.

On November 2, 2014, Skrine collected a season-high nine combined tackles in the Browns' 22–17 victory against the Tampa Bay Buccaneers in Week 9.

Head coach Todd Bowles officially named him the third cornerback on the depth chart to start the regular season, behind Darrelle Revis and Antonio Cromartie.

[37] In Week 14, Skrine collected a season-high eight combined tackles, broke up a pass, and made an interception during a 30–8 victory against the Tennessee Titans.

[39] On October 2, 2016, Skrine collected four combined tackles and sacked quarterback Russell Wilson during a 27–17 loss to the Seattle Seahawks in Week 4.

On October 23, 2016, Skrine recorded a season-high six combined tackles, deflected a pass, and returned an interception by Joe Flacco for a 51-yard gain in the Jets' 24–16 win against the Baltimore Ravens in Week 7.

[41] Defensive coordinator Kacy Rodgers retained Skrine as the starting cornerback to begin the regular season, alongside Morris Claiborne, after the Jets released Darrelle Revis.

[42] In Week 3, Skrine collected a season-high eight solo tackles and sacked quarterback Jay Cutler in the Jets' 20–6 win against the Miami Dolphins.

[53] Skrine began teaching high-intensity interval training classes during the 2017 offseason out of the Kore studio located in New York City's Meatpacking District.

Skrine was arrested at Toronto Pearson International Airport after he had made travel arrangements to return to the United States.